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Abstract

 BACK GROUND:Epstein- Barr virus (EBV) is well known to infect the vast majority of the world's adult population andhas recently been reported in many literatures for its association with a broad spectrum of benign andmalignant tumors, including breast cancer.OBJECTIVE:To analyze the relations and impact of Epstein Barr Virus- latent membrane protein 1(EBV-LMP 1)expression on a group of tissues with primary invasive breast cancers.PATIENTS AND METHODS:Forty- nine (49) formalin-fixed, paraffin- embedded breast tissues were obtained in this study; (34)biopsies from breast cancers (BC) and (15) from apparently normal breast autopsies control group.Detection of expression of Epstein Barr Virus- latent membrane protein 1(EBV-LMP 1) was done byHRP/DAB immunohistochemistry detection kit (an immunoenzymatic antigen detection system forimmunohistochemistry techniques) using specific primary antibodies for EBV-LMP 1.RESULTS:Detection of EBV-LMP 1 - immunohistochemical (IHC) reactions in tissues with BC was observed in11 out of 34 (32.4%), while in healthy breast tissues in the control group was detected in 13.3% (2 outof 15). The difference between the percentages of EBV-LMP 1 detection in BC tissues & control groupwas statistically not significant (P >0.05).While no significant differences were observed between EBV-LMP 1 detection in BC tissues & the ageof patients as well as grade of invasive breast cancers (P value > 0.05).CONCLUSION:Our results indicate that EBV could have a role in the pathogenesis of subset of breast cancers andcontribution in their carcinogenesis.

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