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Abstract

ABSTRACT: BACKGROUND: β-Thalassemia is an inhereted hemoglobin disorder characterized by the absence or reduced synthesis of the β-globin chain. Several immunological defects can be found in patients with β-thalassaemia. Increased IL-8 level was documented in patients with β-thalassaemia and it is probably due to overstimulation of macrophages. OBJECTIVE: Evaluation of serum levels of IL-8, soluble IL-2 Receptor, and serum ferritin in the splenectomized and the non-splenectomized β-thalassemia major patients. METHODS: A cross sectional study was conducted on 60 patients with homozygous β-thalassemia major who were attending Al Karama Teaching hospital from May 2011 to Auguest 2011. Place of work was Al-Kadhmia and Al Karama teaching hospital. Patients were divided into two groups; thirty splenectomized, thirty non-splenectomized, and thirty healthy age and sex matched as control group. RESULT: The mean level of IL-8 was increased in both groups of thalassaemia with significantly higher in the splenectomized 333.06±255.50 pg/ml compare to the non-splenectomized 118.61±46.59 pg/ml and the control 38.39±9.52 pg/ml , P-value

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