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Abstract

BACKGROUND: Metabolic syndrome is a disorder of energy utilization and storage. It is a multi-component disease brought on by a combination of life style and environmental factors, with some populations exhibiting a genetic predisposition and type 2 diabetes. It is marked by abdominal obesity, elevated levels of triglyceride, low levels of HDL (good) cholesterol, high blood pressure and high blood sugar levels. Metabolic syndrome is a significant risk factor for the development of both type 2 diabetes and heart disease, also associated with fatty liver, and polycystic ovary syndrome. Recently two adipocytokines secreted from visceral adipose tissue leptin and adiponectin, have been recognized as key regulators of various metabolic disorder. OBJECTIVE: The objective of this study was to use the adiponectin to leptin ratio as a parameter and a lab index to predict metabolic syndrome across adult males. METHOD: A total of 82 adult males with mean age of (38.47 + 9.27) were included in the study. Fifty eight (58) adult males were the metabolic syndrome group depending on the presence of any 3 out of 5 of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII) criteria which include the following: (central obesity ≥ 102cm, triglyceride ≥150 mg/dl, HDL-Cholesterol ˂40 mg/dl, blood pressure ≥ 130/85 mmHg and fasting serum glucose ≥100 mg/dl) as compared to twenty four (24) healthy adult males as the control group. RESULT: The findings showed that adiponectin/ Leptin ratio is significantly lower in metabolic syndrome adult males as compared to healthy adult males. CONCLUSION: In conclusion data indicate that adiponectin/leptin ratio is a plausible index for detecting the presence of metabolic syndrome in adult males.

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