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Abstract

ABSTRACT: BACKGROUND: Diabetes in pregnancy has a major health risk to the mother and the fetus. Neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) were shown to be as important markers of inflammation in neoplasms, cardiac diseases and diabetes-associated complications. OBJECTIVE: To estimate the mean Lymphocyte, Neutrophil, Platelet, PLR, NLR in diabeticand non-diabetic pregnant women and to identify the correlation between NLR and PLR with each type of diabetes in pregnancy. PATIENTS AND METHODS: A case control study was conducted to determine the relationshipbetween (PLR) and (NLR) in 2 groups of pregnant women; in Diabetic Centre and outpatient clinics, Maternity Teaching Hospital, Kurdistan region, Iraq from 21st February 2019 to 15th September 2019. Study included 100 pregnant women 24-36 weeks gestation after exclusion of cardiovascular risk factors and underlying chronic inflammatory conditions. Group 1 included 50 diabetic women having positive 75g-OGTT(gestational DM) or known cases of type 1 or 2 diabetes mellitus. Group 2 were control group having negative 75g-OGTT . RESULTS: The neutrophil count was significantly higher in the diabetic group .No significantdifferences were detected between the two study groups regarding the platelets (p = 0.225), lymphocytes (p = 0.251), NLR (p = 0.121), PLR (p = 0.784) except for the difference between type II diabetes and the control group where the mean NLR among type II diabetics was 3.86 and that of the control was 3.16 (p = 0.029). CONCLUSION: We could only find significant difference in terms of NLR in type 2diabetes mellitus when compared to the comparison group and in terms of PLR in type 2 diabetes mellitus when compared to the gestational diabetes group.  

DOI

10.52573/ipmj.2020.170489

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