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Abstract

ABSTRACT: BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common cause of hyperandrogenism, and anovulatory infertility; it affects 5-10 % of females at their reproductive age. Prostate specific antigen is a glycoprotein that is secreted from the prostate in males and from paraurethral glands and breast in female. OBJECTIVE: To evaluated the total and free prostate specific antigen levels in female with PCOS, and find out its relation with FSH, LH, Prolactin and testosterone (F,T). METHODS: Eight patients with PCOS diagnosed based on three criteria * High LH: FSH ratio; LH luteinizing hormone to FSH follicle stimulating hormone is 2:1 or more particularly in the early phase of menstrual cycle (3-6) day. * Ultrasound reveals polycystic ovaries * Biomedical hyperandrogenism. ; Elevated androgens particularly free testosterone. Forty normal fertile females served as a control group in this study . Blood samples were taken from all individuals from 3-6 day of menstrual cycle to measure total and free prostate specific antigen, total and free testosterone ( by enzyme linked immunosorbent assay) and FSH,LH, Prolactin (by Immunoradiometric assay). RESULTS: Patients with PCOS and controls differed significantly in all parameters studied, except FSH (P >0.05). LH and LH: FSH ratio were significantly elevated in PCOS group compared to normal control group (11.9±5.4 vs. 7.0±0.6) and (2.3±1.1 vs. 1.2±0.1) respectively. Total and free testosterone were significantly elevated in patient with PCOS compared to normal control group (50±9.6 vs 24 ±3.4 ) and (8.9 ±1.0 vs 1.9±0.4) respectively . Total and free PSA significantly elevated in patient with PCOS compared to normal control group (1.2±0.4 vs 0.1±0.02) and (0.04±0.01 vs 0.01±0.003) respectively. Positive correlation between T-PSA, F-PSA and T-testo, F –testo CONCLUSION: Total and free serum prostate specific antigen levels are higher in patient with PCOS. Serum PSA measurement might be marker of hyperandrogenism in females suffering from PCOS

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